What is an important characteristic of endotoxins in relation to medical devices?

• A. They are easily eliminated during cleaning
• B. They contribute to pyrogens found on medical device surfaces
• C. They are harmless once the device is sterilized
• D. They enhance the effectiveness of disinfectants

Answer: (B)

Endotoxins are components of the outer membrane of Gram-negative bacteria and are significant in the context of medical devices due to their ability to stimulate fever and other inflammatory responses in patients. When endotoxins are present on the surfaces of medical devices, they can act as pyrogens, substances that can induce fever when introduced into the body. This is particularly important in ensuring that medical devices are free from contamination, as even a small amount of endotoxin can elicit a considerable immune response.

The presence of endotoxins is a critical consideration for device manufacturers and cleaning processes, as these contaminants are resilient and can withstand standard cleaning and sterilization procedures. It's crucial that devices are not only sterilized but also effectively tested to ensure that endotoxin levels are within acceptable limits before they are used in medical settings.